GPCR Modeling - Project
G-protein coupled receptors (GPCRs), also known as seven transmembrane receptors (7TM receptors), are the largest family of α-helical transmembrane proteins.
The functions of GPCRs are as diverse as their ligands are. They are responsible for several automatic body functions as blood pressure and heart rate, digestive processes and regulation of the immune system activity.
Also many wide-spreaded and some serious diseases are related to dysfunctions of this receptors, e.g. hypertension, asthma, allergic reactions, schizophrenia, and Parkinson's disease, to mention only a few.
Because structural information for GPCRs is still limited (you can see the 7 available crystal structures on the right side, December 2011), but the demand is very high, we explore the applicability of in silico modeling strategies on this protein family.
The functions of GPCRs are as diverse as their ligands are. They are responsible for several automatic body functions as blood pressure and heart rate, digestive processes and regulation of the immune system activity.
Also many wide-spreaded and some serious diseases are related to dysfunctions of this receptors, e.g. hypertension, asthma, allergic reactions, schizophrenia, and Parkinson's disease, to mention only a few.
Because structural information for GPCRs is still limited (you can see the 7 available crystal structures on the right side, December 2011), but the demand is very high, we explore the applicability of in silico modeling strategies on this protein family.
Programming Languages
